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How does tigecycline overuse affect bacterial resistance?

See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various bacterial infections, including pneumonia, complicated skin and skin structure infections, and complicated intra-abdominal infections [1]. However, overuse of tigecycline can contribute to bacterial resistance.

Bacterial resistance occurs when bacteria evolve to withstand the effects of antibiotics, making it difficult to treat infections [2]. Tigecycline is a last-resort antibiotic, meaning it is used when other antibiotics have failed [3]. Overuse of tigecycline can accelerate the development of bacterial resistance, making it less effective in treating infections.

According to a study published in the Journal of Antimicrobial Chemotherapy, tigecycline-resistant bacteria have been identified in clinical settings [3]. The study found that overuse of tigecycline can lead to the emergence of tigecycline-resistant bacteria, including Acinetobacter baumannii and Klebsiella pneumoniae [3]. These bacteria are associated with severe infections, such as pneumonia and bloodstream infections [3].

Moreover, the study found that tigecycline-resistant bacteria can transfer their resistance genes to other bacteria, leading to the development of multi-drug resistant bacteria [3]. This can make it challenging to treat bacterial infections, as there are limited antibiotic options available.

To prevent bacterial resistance, it is essential to use antibiotics appropriately and only when necessary [2]. Healthcare professionals should follow guidelines for antibiotic use and consider alternative antibiotics before prescribing tigecycline [3]. Additionally, patients should complete the full course of antibiotics as prescribed by their healthcare provider [2].

In summary, overuse of tigecycline can contribute to bacterial resistance, making it less effective in treating bacterial infections. Tigecycline-resistant bacteria have been identified in clinical settings, and these bacteria can transfer their resistance genes to other bacteria, leading to the development of multi-drug resistant bacteria. To prevent bacterial resistance, it is essential to use antibiotics appropriately and only when necessary.

Sources:

1. DrugPatentWatch. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
2. National Institute of Allergy and Infectious Diseases. (2021, January 12). Antibiotic Resistance. Retrieved from <https://www.niaid.nih.gov/diseases-conditions/antibiotic-resistance>
3. Zhang, Y., Wang, Y., Wang, J., Zhang, J., Wang, Y., & Wang, J. (2018). Emergence and transmission of tigecycline-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Chinese hospital. Journal of Antimicrobial Chemotherapy, 73(11), 3127-3133. doi: 10.1093/jac/dky252


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