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Can you take Lipitor with over-the-counter pain relievers? Lipitor is a statin used to lower cholesterol. Many people take it daily and also use OTC pain relievers. The main risk comes from combining it with ibuprofen or naproxen. Why do some people worry about taking ibuprofen with Lipitor? Ibuprofen belongs to a class of drugs called NSAIDs. NSAIDs can raise the risk of muscle problems in people who take statins. Muscle pain, weakness, or rhabdomyolysis, a serious breakdown of muscle tissue, is rarer but possible. Muscle symptoms are more likely when NSAID levels stay high in the body. How does naproxen interact with Lipitor? Naproxen is another NSAID. It has a longer half-life than ibuprofen, so its effect lasts longer. It can also erodes the stomach lining over time. Stomach bleeding becomes a risk when both NSAID and statin use occurs. Stomach bleeding is rarer in young, healthy patients but higher in older adults. What happens when you use acetaminophen instead? Acetaminophen is not an NSAID. It lacks the muscle and stomach risks that NSAIDs bring. It still carries a risk of liver damage when taken in high doses. Liver problems occur mainly when patients exceed 3,000 mg per day or when they already have liver issues. What price difference exists between branded Lipitor and generics? Branded Lipitor costs far more than its generic form. Generics trade under the name atorvastatin calcium. Generics remain cheaper than branded versions because patents expired in 2011.
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