What are the common side effects in older adults?
Cosentyx, a biologic medication used to treat psoriatic arthritis, plaque psoriasis, and other autoimmune conditions, has a well-established safety profile in various age groups. According to the manufacturer, Novartis, the most common side effects in older adults (≥ 65 years) include [1]:
* Injection site reactions, such as pain, redness, and swelling
* Headache
* Fatigue
* Nausea
* Vomiting
* Diarrhea
These side effects are typically mild to moderate in severity and usually resolve on their own or with minimal treatment [1].
What are the potential increased risks in older adults?
While Cosentyx is generally considered safe for older adults, there are some potential increased risks to be aware of [1]:
* Increased risk of infections, including serious infections such as pneumonia, bronchitis, and sinusitis
* Increased risk of blood disorders, including anemia and decreases in blood count
* Increased risk of nervous system disorders, including seizures and peripheral neuropathy
Can older adults take Cosentyx if they have comorbidities?
The safety and efficacy of Cosentyx have not been established in patients with certain comorbidities, such as [1]:
* Chronic hepatitis B or C
* Chronic or recurrent infections (e.g., sepsis, pneumonia, tuberculosis)
* History of tuberculosis
* Moderate or severe renal impairment
* Moderate or severe hepatic impairment
How does Cosentyx interact with other medications in older adults?
Cosentyx may interact with certain medications, including warfarin, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs), which may increase the risk of bleeding. Additionally, Cosentyx may also interact with other immunosuppressants and biologic medications, which may increase the risk of infections.
When does the patent for Cosentyx expire?
The patent for Cosentyx expired in 2019 in the United States, and several biosimilar versions of the medication are now available [2].
Sources:
[1] Novartis Pharmaceuticals Corporation. (2022). Cosentyx Highlights of Prescribing Information. Retrieved from https://www.cosentyx.com/static/cmsasset/0a4e5a41-2dd1-4e9c-b9eb-b7c9e9cbe6ac/cosentyx_pi.pdf
[2] DrugPatentWatch.com. (2022). Cosentyx. Retrieved from https://www.drugpatentwatch.com/cosentyx