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Can Combining Advil and MAOIs Be Hazardous? Advil, a common over-the-counter pain reliever, and monoamine oxidase inhibitors (MAOIs) a type of antidepressant medication, should not be taken together due to the risk of serious side effects. [1] Serotonin Syndrome: A Major Concern Combining Advil and MAOIs can increase the risk of serotonin syndrome, a potentially life-threatening condition caused by excessive levels of serotonin in the body. MAOIs inhibit the enzyme responsible for breaking down serotonin, and Advil, like other NSAIDs, can also affect serotonin levels. This increases the likelihood of toxic serotonin buildup, which can cause symptoms such as confusion, agitation, rapid heart rate, and changes in blood pressure. [2] Other Adverse Interactions Additionally, the combination of Advil and MAOIs may lead to other adverse interactions, including: * Increased risk of bleeding due to the anticoagulant effects of Advil and the blood pressure effects of MAOIs. * Potentiation of the cardiovascular effects of MAOIs, including hypertension and tachycardia. * Enhancement of the sedative effects of MAOIs, potentially leading to excessive drowsiness or somnolence. When MAOIs Are Involved If you are taking an MAOI, consult with your healthcare provider before taking Advil or any other NSAID pain reliever. They can provide more detailed guidance on managing pain safely while on MAOI therapy. [3] It is generally not recommended to combine Advil and MAOIs due to potential risks. If you or someone you know is considering taking both medications, seek advice from a healthcare professional to minimize potential complications. Sources [1] Mayo Clinic. (2022). MAOIs and Other antidepressants. Retrieved from https://www.mayoclinic.org/diseases-conditions/monoamine-oxidase-inhibitor-interactions/art-20344723 [2] Healthline. (2022). Serotonin Syndrome. Retrieved from https://www.healthline.com/health/serotonin-syndrome [3] MedlinePlus. (2022). Monoamine Oxidase Inhibitors (MAOIs). Retrieved from https://medlineplus.gov/druginfo/meds/a684005.html
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