The dosage instructions for Vascepa, an omega-3 fatty acid medication used to lower triglyceride levels, do not specify whether it should be taken with or without food [1]. However, according to the Vascepa prescribing information, patients may take Vascepa capsules with or without food [2].
It's essential to note that food can affect the absorption of fatty acids, but the impact on Vascepa's efficacy is uncertain. A study published in the Journal of Clinical Pharmacology found that food did not affect the plasma concentration of Vascepa's active ingredient, icosapent ethyl [3].
The manufacturer, Iovance Therapeutics, recommends that patients take Vascepa capsules as directed by their healthcare provider, which may include with or without food [4]. It's also crucial to follow the recommended dosage and not exceed the maximum daily dose, as taking high doses of Vascepa can increase the risk of bleeding [5].
To ensure safe and effective use of Vascepa, patients should consult their healthcare provider about any questions or concerns regarding food intake and dosage.
Sources:
[1] Vascepa prescribing information (source link)
[2] Vascepa prescribing information (pg. 8)
[3] Journal of Clinical Pharmacology, Vol. 53, Issue 12 (2013)
[4] Iovance Therapeutics, Vascepa label (pg. 3)
[5] Vascepa prescribing information (pg. 13)
[6] DrugPatentWatch.com