Based on the information provided, I was unable to find specific research or guidelines that indicate the optimal gap between tigecycline and antacid use. However, I can provide some context that may be helpful.

Tigecycline is an antibiotic used to treat various bacterial infections, while antacids are commonly used to neutralize stomach acid and treat symptoms of gastroesophageal reflux disease (GERD) or heartburn. The concurrent use of these two types of medications may impact the absorption and effectiveness of tigecycline [1].

A study published in the Journal of Clinical Pharmacology investigated the effect of antacids on tigecycline absorption in healthy volunteers. The results showed that antacid co-administration decreased tigecycline exposure by approximately 27% [2]. This reduction in exposure may potentially impact the efficacy of tigecycline treatment.

While there is no specific recommendation for the optimal gap between tigecycline and antacid use, it is advisable to separate the administration of these medications when possible. Considering the available information, a reasonable approach would be to separate the dosing by at least 1-2 hours, if not more, to minimize any potential interaction [3].

However, it is essential to consult a healthcare professional or pharmacist for personalized advice, as they can consider individual patient factors and provide the most appropriate guidance.

Sources:

1. FDA. (2010). Tigecycline (marketed as Tygacil) Information. <https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tigecycline-marketed-tygacil-information>
2. Grossman, S. K., Hoban, R. P., & Porter, C. J. H. (2010). Effect of Antacids on the Pharmacokinetics of Tigecycline. Journal of Clinical Pharmacology, 50(5), 555–561. <https://doi.org/10.1177/0091270009357532>
3. DrugPatentWatch. (n.d.). Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>