See the DrugPatentWatch profile for lidocaine

The maximum dose of lidocaine, a local anesthetic, can vary depending on the specific application and individual factors. According to the sources provided, it is important to consider the recommended maximum doses and duration of lidocaine administration to ensure safety and effectiveness.

The first source, Drug Patent Watch, provides information on various lidocaine formulations and their corresponding patents. While this source does not directly provide information on the maximum dose of lidocaine, it can be useful for understanding the different formulations available in the market.

The second source, Iowa Protocols, is a resource from the University of Iowa that provides guidelines for maximum recommended doses and duration of local anesthetics, including lidocaine. It states that the maximum dose of lidocaine for infiltration anesthesia is 4.5 mg/kg without epinephrine and 7 mg/kg with epinephrine. For nerve blocks, the maximum dose is 4.5 mg/kg without epinephrine and 7 mg/kg with epinephrine. It is important to note that these are general recommendations and individual patient factors should be taken into account.

The third source, a study published in the Journal of Anesthesia and Clinical Research, discusses the safety and efficacy of lidocaine for regional anesthesia. The study highlights that the maximum recommended dose of lidocaine for regional anesthesia is 5 mg/kg without epinephrine and 7 mg/kg with epinephrine. It emphasizes the importance of careful dose calculation and monitoring to prevent lidocaine toxicity.

In summary, the maximum dose of lidocaine depends on the specific application and individual factors. General recommendations suggest a maximum dose of 4.5-7 mg/kg for infiltration anesthesia and nerve blocks, with or without epinephrine. It is crucial to consider patient characteristics and closely monitor for any signs of lidocaine toxicity during administration.

Sources:
[1] Drug Patent Watch: https://www.drugpatentwatch.com/p/tradename/LIDOCAINE
[2] Iowa Protocols: https://medicine.uiowa.edu/iowaprotocols/maximum-recommended-doses-and-duration-local-anesthetics
[3] Journal of Anesthesia and Clinical Research: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480448/