Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels and prevent heart disease [1]. There is no direct evidence to suggest that Lipitor affects flexibility in hot yoga. However, it is important to note that hot yoga can have potential risks and side effects, particularly for individuals with certain medical conditions or who are taking certain medications, such as Lipitor [2].

Hot yoga is typically performed in a room heated to around 105 degrees Fahrenheit with a humidity level of 40% [2]. This environment can cause dehydration, overheating, and potential cardiovascular strain, which can be dangerous for individuals with certain medical conditions, such as high blood pressure or heart disease. Lipitor is also known to have potential side effects, including muscle pain and weakness, which could affect one's ability to perform yoga poses [3].

Therefore, it is important for individuals taking Lipitor to consult with their healthcare provider before starting a hot yoga practice. They should also monitor their body's response to the heat and humidity during the practice and stay hydrated throughout the session. It is also recommended that individuals with certain medical conditions, such as heart disease, avoid hot yoga altogether [2].

In conclusion, there is no direct evidence to suggest that Lipitor affects flexibility in hot yoga. However, individuals taking Lipitor should consult with their healthcare provider before starting a hot yoga practice and monitor their body's response to the heat and humidity during the session. It is also important to be aware of the potential risks and side effects associated with hot yoga, particularly for individuals with certain medical conditions [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.everydayhealth.com/yoga/hot-yoga-it-safe-how-hot-does-it-get/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463373/