Acetaminophen is a commonly used over-the-counter pain reliever and fever reducer. It is generally considered safe for most people, including those with allergies. However, it is important to note that there have been rare cases of serious skin reactions associated with the use of acetaminophen.

According to the FDA, there have been reports of rare but serious skin reactions, such as Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN), associated with the use of acetaminophen. These reactions are very rare, but they can be life-threatening. The FDA advises individuals to stop taking acetaminophen and seek medical attention immediately if they experience any signs of a skin reaction, such as rash, blisters, or skin peeling.

It is also important to be aware of any potential allergies to acetaminophen itself. While rare, some individuals may be allergic to acetaminophen and may experience symptoms such as hives, itching, or difficulty breathing. If you have a known allergy to acetaminophen, it is best to avoid using it and consult with a healthcare professional for alternative pain relief options.

If you have allergies to other substances, such as pollen or pet dander, you may want to consider using combination products that include both acetaminophen and an antihistamine, such as chlorpheniramine. These combination products can provide relief for both pain and allergy symptoms. However, it is important to read the labels carefully and follow the recommended dosage instructions.

In summary, acetaminophen is generally safe for most people, including those with allergies. However, there have been rare cases of serious skin reactions associated with its use. If you experience any signs of a skin reaction or have a known allergy to acetaminophen, it is best to stop using it and seek medical attention. Always read and follow the label instructions and consult with a healthcare professional if you have any concerns or questions.

Sources:
[1] Drug Patent Watch. "Acetaminophen." https://www.drugpatentwatch.com/p/tradename/ACETAMINOPHEN
[2] FDA. "Questions and Answers: FDA warns of rare but serious skin reactions with the pain reliever/fever reducer acetaminophen." https://www.fda.gov/drugs/drug-safety-and-availability/questions-and-answers-fda-warns-rare-serious-skin-reactions-pain-relieverfever-reducer-acetaminophen
[3] WebMD. "Allergy Relief/Chlorpheniramine-Acetaminophen Oral." https://www.webmd.com/drugs/2/drug-161605/allergy-reliefchlorpheniramine-acetaminophen-oral/details