Yes, there can be long-term effects of Methotrexate use. Methotrexate is a medication commonly used to treat certain types of cancer, rheumatoid arthritis, and severe psoriasis. While it can be effective in managing these conditions, long-term use can lead to several side effects.

One of the primary long-term effects of Methotrexate is liver toxicity [1]. Prolonged use can cause scarring of the liver, leading to liver fibrosis or cirrhosis. Regular monitoring of liver function is therefore recommended for individuals on long-term Methotrexate therapy.

Methotrexate can also affect the immune system, making users more susceptible to infections [1]. Long-term use can further increase this risk.

Additionally, Methotrexate can cause lung damage, including inflammation and scarring of the lungs, particularly in individuals with pre-existing lung conditions [1].

Furthermore, Methotrexate can lead to decreased fertility in both men and women [1]. Women of childbearing age should use effective contraception while on Methotrexate, as it can cause birth defects if taken during pregnancy.

Finally, Methotrexate can cause mouth sores, hair loss, and stomach upset, although these side effects are more common during the initial stages of treatment and often improve over time [1].

It is important to note that the risk and severity of these long-term effects can vary greatly depending on the individual's health status, the dose and duration of Methotrexate use, and other factors [1]. Regular follow-ups with healthcare providers are crucial for individuals on long-term Methotrexate therapy to monitor for and manage these potential side effects.

Sources:
[1] DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from https://www.drugpatentwatch.com/drugs/methotrexate