There is no definitive scientific consensus on whether probiotics directly affect Lipitor's cholesterol-lowering impact [1]. However, some studies suggest that certain strains of probiotics may help lower cholesterol levels [2][3].

Lipitor, a medication used to treat high cholesterol, works by inhibiting HMG-CoA reductase, an enzyme involved in the production of cholesterol in the body [4]. Probiotics, on the other hand, are live bacteria and yeasts that are beneficial for health, especially the digestive system [5].

While some research indicates that certain strains of probiotics may help lower cholesterol by breaking down bile in the gut, which can then be excreted from the body, thus preventing its reabsorption and conversion back into cholesterol [2][3], it is unclear whether this effect is significant enough to impact Lipitor's cholesterol-lowering abilities.

It is important to note that while probiotics may offer some health benefits, they should not be used as a substitute for prescribed medications like Lipitor [6]. Patients should consult with their healthcare providers before starting any new supplements or making significant changes to their diet and lifestyle.

In summary, while some studies suggest that probiotics may have a modest cholesterol-lowering effect, there is no clear evidence that they directly affect Lipitor's cholesterol-lowering impact.

Sources:

1. <https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know>
2. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265905/>
3. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720433/>
4. <https://www.drugs.com/lipitor.html>
5. <https://www.healthline.com/nutrition/what-are-probiotics>
6. <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/probiotics/art-20046563>
7. <https://www.drugpatentwatch.com/drugs/lipitor>