Before taking Lipitor with antidepressants, it is recommended to consult with a doctor. Lipitor is a prescription medication that is used to lower cholesterol levels in the body [1]. Antidepressants are used to treat depression, anxiety, and other mental health disorders. Some antidepressants can interact with Lipitor, which can cause adverse side effects [2].

St. John's Wort is an herbal supplement that is sometimes used to treat depression. However, it can also interact with Lipitor and other medications. St. John's Wort can increase the metabolism of Lipitor, which can reduce its effectiveness [2].

Grapefruit is another substance that can interact with Lipitor. Grapefruit can increase the levels of Lipitor in the body, which can increase the risk of side effects [3].

Therefore, it is important to consult with a doctor before taking Lipitor with antidepressants, St. John's Wort, or grapefruit. The doctor can evaluate the potential risks and benefits of taking these medications together and can provide guidance on how to safely use them.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.mayoclinic.org/drugs-supplements-st-johns-wort/art-20362212
[3] https://www.nhs.uk/common-health-questions/medicines/does-grapefruit-affect-my-medicine/