There is no definitive evidence to suggest that fatty food consumption reduces Lipitor's effectiveness [1]. Lipitor, a statin, works by blocking a substance your body needs to make cholesterol [2]. The effectiveness of Lipitor is more closely related to factors such as the dosage, the individual's metabolism, and compliance with the medication regimen [3][4]. However, it is generally recommended to maintain a heart-healthy diet, which includes limiting the intake of saturated and trans fats, for overall cardiovascular health [5].

Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/medications-treatments/ncv-20266593
[3] https://www.webmd.com/cholesterol-management/lipitor-atorvastatin
[4] https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/lipitor-atorvastatin-calcium-information
[5] https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/saturated-fats