Lipitor is a medication used to lower cholesterol levels in the body. Grapefruit is a fruit that is known to interact with some medications, including Lipitor. According to Drug Patent Watch [1], Lipitor's active ingredient, atorvastatin, is metabolized by an enzyme in the liver called CYP3A4. Grapefruit juice can inhibit this enzyme, which can increase the amount of Lipitor in the bloodstream and lead to potential side effects.

GoodRx [2] states that consuming grapefruit or grapefruit juice while taking Lipitor can increase the risk of side effects such as muscle pain, liver damage, and kidney damage. This is because the higher levels of Lipitor in the bloodstream can increase the likelihood of these side effects occurring. GoodRx recommends avoiding grapefruit and grapefruit juice while taking Lipitor.

Ro [3] also warns against consuming grapefruit or grapefruit juice while taking Lipitor. They explain that grapefruit can increase the absorption of Lipitor, leading to higher levels of the medication in the bloodstream. This can increase the risk of side effects such as muscle pain, liver damage, and kidney damage. Ro recommends avoiding grapefruit and grapefruit juice while taking Lipitor.

In conclusion, combining Lipitor and grapefruit can increase the risk of side effects such as muscle pain, liver damage, and kidney damage. It is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor. Patients should consult their healthcare provider if they have any questions or concerns about taking Lipitor with other medications or foods.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin
[3] https://ro.co/health-guide/lipitor-and-grapefruit/