Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections [1]. However, like other antibiotics, tigecycline can have side effects, particularly on the gut microbiota.

According to a study published in the Journal of Chemotherapy, tigecycline can cause long-term changes in the gut microbiota [2]. The study found that tigecycline treatment led to a decrease in the diversity of the gut microbiota, which can make individuals more susceptible to infections and other health issues [2].

Furthermore, a review published in the Journal of Antimicrobial Chemotherapy found that tigecycline can cause significant alterations in the gut microbiota, leading to the overgrowth of potentially harmful bacteria [3]. This can result in conditions such as Clostridioides difficile infection (CDI), which can cause severe diarrhea and other gastrointestinal symptoms [3].

It is important to note that the long-term effects of tigecycline on the gut microbiota are not fully understood, and more research is needed to determine the full extent of these effects [2]. However, healthcare providers should be aware of the potential risks of tigecycline and consider alternative antibiotics when possible [3].

In summary, tigecycline can cause long-term changes in the gut microbiota, leading to a decrease in diversity and the overgrowth of potentially harmful bacteria. These changes can increase the risk of infections and other health issues. Healthcare providers should consider these risks when prescribing tigecycline.

Cited sources:
[1] <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
[2] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701508/>
[3] <https://pubmed.ncbi.nlm.nih.gov/31629863/>