Lipitor is a medication used to lower cholesterol levels in the body. Grapefruit and grapefruit juice contain compounds that can interfere with the metabolism of certain drugs, including Lipitor. This can increase the concentration of the drug in the bloodstream, leading to potential side effects [2]. The interaction between grapefruit and Lipitor is due to the inhibition of an enzyme in the liver called CYP3A4, which is responsible for breaking down Lipitor. Grapefruit contains furanocoumarins, which inhibit the activity of this enzyme and increase the concentration of Lipitor in the bloodstream [3].

Consuming grapefruit or grapefruit juice while taking Lipitor can increase the risk of side effects, including muscle pain, weakness, and rhabdomyolysis, a serious condition that can cause muscle damage and kidney failure [2]. The risk of side effects is higher in people who consume large amounts of grapefruit or grapefruit juice, or who take Lipitor in higher doses [3].

It is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor. If you are taking Lipitor and have concerns about consuming grapefruit, you should talk to your doctor or pharmacist for advice [2]. It is important to follow the prescribed dosage and not to adjust the medication without consulting a healthcare professional.

Sources:
[2] https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin
[3] https://ro.co/health-guide/lipitor-and-grapefruit/