Lipitor, a statin medication, is commonly prescribed to lower cholesterol levels. Several factors can influence the degree to which cholesterol drops with Lipitor treatment.

1. Baseline cholesterol levels: Individuals with higher baseline cholesterol levels tend to experience a more significant reduction in cholesterol with Lipitor treatment [1].

2. Dosage: Higher Lipitor dosages generally result in greater cholesterol reductions [1]. However, the optimal dosage varies for each person and should be determined by a healthcare professional.

3. Compliance: Consistent medication use is crucial for achieving and maintaining cholesterol reduction [1]. Missed doses or early discontinuation of Lipitor can hinder cholesterol reduction.

4. Lifestyle factors: Adopting a heart-healthy lifestyle can enhance Lipitor's cholesterol-lowering effects [1]. Factors include:
- Diet: Consuming a diet low in saturated and trans fats, and rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
- Exercise: Engaging in regular physical activity, such as brisk walking, cycling, or swimming, for at least 30 minutes per day, most days of the week.
- Weight management: Maintaining a healthy weight or losing weight if overweight.
- Avoiding tobacco: Refraining from smoking or using tobacco products.
- Limiting alcohol: Consuming alcohol in moderation, if at all, defined as up to one drink per day for women and up to two drinks per day for men.

5. Genetic factors: Certain genetic variations can affect an individual's response to Lipitor and other statins [1]. Genetic testing may help identify individuals who are less likely to respond to statin therapy.

6. Drug interactions: Concomitant use of certain medications can affect Lipitor's cholesterol-lowering efficacy [1]. Examples include:
- Fibrates: These cholesterol-lowering medications can increase the risk of muscle damage when taken with Lipitor.
- Cyclosporine: This immunosuppressant drug can increase Lipitor levels, potentially leading to increased side effects and reduced cholesterol reduction.
- Grapefruit juice: Consuming grapefruit juice can increase Lipitor levels, potentially leading to increased side effects and reduced cholesterol reduction.

Sources:
[1] DrugPatentWatch.com. (n.d.). Lipitor (atorvastatin) - DrugPatentWatch. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor