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What liver meds are contraindicated with lipitor?

Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the sources provided, there are certain liver medications that are contraindicated with Lipitor.

The first source, Drug Patent Watch [1], does not provide any information on the contraindications of Lipitor with liver medications.

The second source, a book chapter from the National Center for Biotechnology Information [2], states that "the concomitant use of atorvastatin with drugs that inhibit cytochrome P450 3A4 is contraindicated." Cytochrome P450 3A4 is an enzyme that is involved in the metabolism of many drugs, including Lipitor. Some liver medications, such as azole antifungals, macrolide antibiotics, and protease inhibitors, inhibit this enzyme and can increase the concentration of Lipitor in the blood, leading to an increased risk of side effects. Therefore, it is important to avoid using these medications with Lipitor.

The third source, a Drug Safety Communication from the US Food and Drug Administration [3], also warns about the use of certain medications with Lipitor. The communication states that the label for Lipitor has been updated to include information about the increased risk of myopathy (muscle damage) when Lipitor is used concomitantly with certain medications, including fibrates, niacin, and cyclosporine. Fibrates and niacin are medications used to lower cholesterol levels, while cyclosporine is an immunosuppressant used to prevent rejection of transplanted organs. These medications can also increase the concentration of Lipitor in the blood and lead to an increased risk of myopathy.

In summary, the sources suggest that certain liver medications that inhibit cytochrome P450 3A4, such as azole antifungals, macrolide antibiotics, and protease inhibitors, are contraindicated with Lipitor. Additionally, fibrates, niacin, and cyclosporine are also contraindicated with Lipitor due to the increased risk of myopathy. It is important to consult with a healthcare provider before taking any medications with Lipitor.


Follow-up:   Why are some liver meds contraindicated with Lipitor? What are the potential risks of taking Lipitor with liver meds? Are there any alternative liver meds to take with Lipitor?

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