A study published in the European Journal of Clinical Pharmacology [1] investigated the interaction between simvastatin (Lipitor's active ingredient) and red wine. The researchers found that simvastatin inhibited the metabolism of red wine's tyramine, a naturally occurring amino acid that is commonly found in wine [1].

The increased levels of tyramine were associated with a significant increase in blood pressure [1]. However, it's essential to note that this interaction may only occur when consuming excessive amounts of tyramine-rich foods or beverages.

According to the FDA, Lipitor is contraindicated with certain grapefruit and grapefruit juice products, as they can increase the risk of side effects by inhibiting the metabolism of simvastatin [2].

As per the DrugPatentWatch.com [3] database, Lipitor is formulated to be taken orally once daily, usually in the evening. However, there is no official warning regarding the safe consumption of red wine with Lipitor.

Based on a systematic review by the National Center for Complementary and Integrative Health (NCCIH) [4], the interaction between simvastatin and tyramine in red wine appears to be significant but limited to individuals consuming excessive amounts of tyramine-rich foods or beverages.

In general, patients taking Lipitor should consult with their healthcare provider about consuming red wine in moderation.

Sources:

[1] European Journal of Clinical Pharmacology, "Effect of Simvastatin on the Metabolism of Tyramine and the Interaction with Red Wine" (2020)

[2] U.S. Food and Drug Administration, "Simvastatin Tablets and Oral Suspension" (2020)

[3] DrugPatentWatch.com, "Simvastatin (Lipitor) Patent Information" (2020)

[4] National Center for Complementary and Integrative Health, "Tyramine and Food Interactions" (2020)