Aspirin, also known as acetylsalicylic acid, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce fever, and prevent blood clots. Aspirin works by inhibiting the production of prostaglandins, which are chemicals that promote inflammation, pain, and fever [2].

When taken orally, aspirin is rapidly absorbed into the bloodstream from the stomach and small intestine [3]. In the stomach, aspirin can irritate the gastric mucosa and cause gastrointestinal (GI) side effects such as nausea, heartburn, and stomach pain [1]. However, these side effects are usually mild and can be minimized by taking aspirin with food or a glass of milk [3].

Aspirin can also affect the digestive system by reducing the production of prostaglandins that protect the stomach lining from acid and digestive enzymes [2]. This can increase the risk of stomach ulcers and bleeding in some people, especially those who are older, have a history of stomach ulcers, or take high doses of aspirin [3].

In summary, aspirin can impact digestion in the stomach by causing GI side effects and reducing the production of prostaglandins that protect the stomach lining. It is important to take aspirin as directed by a healthcare provider and to be aware of the potential side effects.

Sources:
[1] DrugPatentWatch. Aspirin - Trademark Details. Retrieved from https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] Mahmud, H., & Kassam, Z. (2020). Aspirin. In StatPearls [Internet]. StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400979/
[3] Harvard Health Publishing. Answers about aspirin. Retrieved from https://www.health.harvard.edu/heart-health/answers-about-aspirin