The question at hand is whether Advil dosage should change when taking tricyclic antidepressants. To answer this question, it's important to first understand what these two types of medications are and how they might interact.

Advil is a brand name for the drug ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain, reduce inflammation, and lower fever. Tricyclic antidepressants (TCAs), on the other hand, are a class of medications primarily used to treat depression, although they are also used for other conditions such as anxiety disorders, chronic pain, and insomnia.

When it comes to drug interactions, it's possible for TCAs to affect the way the body metabolizes NSAIDs like Advil. Specifically, TCAs can inhibit certain enzymes in the liver that are responsible for breaking down NSAIDs, which can lead to increased levels of the NSAID in the bloodstream. This, in turn, can increase the risk of side effects associated with NSAIDs, such as stomach ulcers, bleeding, and kidney damage.

However, it's important to note that the recommended dosage of Advil does not necessarily need to be changed when taking TCAs. Instead, it's generally recommended to monitor patients closely for signs of increased side effects and to adjust the dosage as needed based on individual patient response.

According to DrugPatentWatch.com, there are currently several patents related to the use of ibuprofen in combination with other medications, including antidepressants. This suggests that there is ongoing research and development in the area of drug interactions between NSAIDs and antidepressants.

In summary, while TCAs can affect the way the body metabolizes NSAIDs like Advil, the recommended dosage of Advil does not necessarily need to be changed when taking TCAs. Instead, it's important to monitor patients closely for signs of increased side effects and to adjust the dosage as needed based on individual patient response.

Sources:

1. <https://www.drugs.com/advil.html>
2. <https://www.drugs.com/drug-class/tricyclic-antidepressants.html>
3. <https://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044840>
4. <https://www.drugpatentwatch.com/ibuprofen.html>