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Can lipitor increase platelet aggregation?



Lipitor, also known as atorvastatin, is a commonly prescribed medication used to lower cholesterol levels and reduce the risk of heart disease [1]. According to a study published in the American Heart Association journal, Circulation, atorvastatin was found to have antiplatelet effects that could potentially reduce the risk of heart attack and stroke [3]. The study found that atorvastatin was able to reduce platelet aggregation, which is the process by which platelets clump together to form blood clots. This antiplatelet effect was found to be independent of the medication's cholesterol-lowering effects.

However, another study published in the National Center for Biotechnology Information found that atorvastatin can also increase platelet aggregation in some patients [2]. The study found that in patients with type 2 diabetes, atorvastatin was associated with increased platelet aggregation. The researchers concluded that this effect may be due to the medication's ability to increase oxidative stress, which can lead to platelet dysfunction.

In conclusion, while atorvastatin has been found to have antiplatelet effects that can potentially reduce the risk of heart attack and stroke, it may also increase platelet aggregation in some patients, particularly those with type 2 diabetes. As with any medication, it is important to discuss the potential risks and benefits with a healthcare provider before starting treatment.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776183/
[3] https://www.ahajournals.org/doi/10.1161/01.cir.0000047060.60595.cc.



Follow-up:   What are the risks of increased platelet aggregation with Lipitor? How does Lipitor affect platelet function? Can Lipitor-induced platelet aggregation be reversed?





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