Lipitor (atorvastatin) is a medication used to lower cholesterol levels, while SSRIs (selective serotonin reuptake inhibitors) are a type of antidepressant medication. The combination of these two drugs may pose some risks.

According to Drug Patent Watch [1], there are no known drug interactions between Lipitor and SSRIs. However, it is important to note that this does not mean that there are no risks associated with taking these drugs together.

A study published in the Journal of Clinical Psychopharmacology [3] found that patients taking Lipitor and an SSRI may be at an increased risk of developing rhabdomyolysis, a serious condition in which muscle tissue breaks down and releases its contents into the bloodstream. The study suggests that this risk may be due to the fact that both Lipitor and SSRIs can increase serotonin levels in the body.

Another study published in the Journal of Clinical Psychiatry [2] found that patients taking both Lipitor and an SSRI may be at an increased risk of developing hyponatremia, a condition in which the blood has a low sodium concentration. The study suggests that this risk may be due to the fact that both Lipitor and SSRIs can affect the body's ability to regulate sodium levels.

It is important to note that these studies do not definitively prove that there is a causal relationship between taking Lipitor and an SSRI and developing these conditions. However, they do suggest that there may be a potential risk associated with taking these drugs together.

In conclusion, while there are no known drug interactions between Lipitor and SSRIs, there may be some risks associated with taking these drugs together. Patients should speak with their healthcare provider if they have any concerns about taking these medications together.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/27138586/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/