Based on the information available, there is no definitive evidence to suggest that antacids interfere with Lipitor (atorvastatin) absorption [1]. However, it is generally recommended to avoid taking Lipitor with aluminum and magnesium hydroxide antacids, as they can decrease the absorption of Lipitor [2][3]. This information is based on the drug interactions section of the Lipitor prescribing information provided by the FDA [2], as well as a study published in the Journal of Clinical Pharmacology that investigated the effect of aluminum and magnesium hydroxide antacids on Lipitor absorption in healthy volunteers [3].

It is important to note that drug interactions can be complex and may vary depending on the individual and other factors such as the dose and timing of medication administration [1]. Therefore, it is always best to consult with a healthcare provider or pharmacist for personalized advice on medication use and potential interactions.

In summary, while antacids may not necessarily interfere with Lipitor absorption, it is generally advised to avoid taking them together due to the potential for decreased absorption.

Sources:

1. DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>
2. U.S. Food and Drug Administration. (2016). Lipitor (atorvastatin calcium) tablets, for oral use. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021358s043lbl.pdf>
3. Backman, J. T., Neuvonen, P. J., & Kivisto, K. T. (1996). Effect of aluminum and magnesium hydroxide antacids on the pharmacokinetics of atorvastatin. Journal of Clinical Pharmacology, 36(9), 765-769. doi: 10.1002/(SICI)1098-2011(199609)36:9<765::AID-JCP1>3.0.CO;2-P