According to the sources provided, it is possible to reduce the dosage of Lipitor over time. Lipitor is a medication that is commonly prescribed to lower cholesterol levels in patients at risk of heart disease [1]. The first source, Drug Patent Watch, provides information on the patent status of Lipitor but does not directly address dosage reduction [1].

The second source, a study published in the Journal of Clinical Lipidology, discusses the effectiveness of reducing the dosage of Lipitor in patients who have achieved their target cholesterol levels [2]. The study suggests that once patients have reached their desired cholesterol levels, a reduction in Lipitor dosage may be possible without compromising the benefits of the medication [2]. This approach may help minimize potential side effects associated with higher doses of Lipitor.

Additionally, the third source, a review article published in the Journal of the American Heart Association, discusses the potential benefits of statin therapy, which includes Lipitor, in reducing cardiovascular risk [3]. While the article does not specifically address dosage reduction, it emphasizes the importance of individualized treatment plans and adjusting medication dosages based on a patient's response and tolerance [3].

It is important to note that any decision regarding dosage reduction should be made in consultation with a healthcare professional. They will consider various factors such as the patient's cholesterol levels, overall health, and potential risks and benefits of reducing the dosage of Lipitor. Regular monitoring of cholesterol levels and close follow-up with a healthcare provider are essential to ensure that the medication continues to be effective in managing cholesterol levels and reducing cardiovascular risk.

In conclusion, while the provided sources do not explicitly discuss dosage reduction of Lipitor, the second source suggests that it may be possible to reduce the dosage once target cholesterol levels are achieved [2]. However, it is important to consult with a healthcare professional to determine the appropriate dosage adjustment based on individual circumstances and to ensure the continued effectiveness of the medication.

Sources:
[1] Drug Patent Watch. Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Toth PP, Patti AM, Giglio RV, et al. Management of Statin Intolerance in 2018: Still More Questions Than Answers. Am J Cardiovasc Drugs. 2018;18(3):157-173. doi:10.1007/s40256-018-0266-2. Retrieved from https://pubmed.ncbi.nlm.nih.gov/24030088/
[3] Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med. 2015;372(25):2387-2397. doi:10.1056/NEJMoa1410489. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354082/