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Who Should Avoid Using Cosentyx: Understanding the Contraindications and Precautions

Cosentyx, a biologic medication, is used to treat various autoimmune diseases, including psoriasis, psoriatic arthritis, and ankylosing spondylitis. While it has shown promising results in many patients, there are certain individuals who should avoid using Cosentyx due to its contraindications and precautions. In this article, we will explore who should avoid using Cosentyx and why.

Who Should Avoid Using Cosentyx: Contraindications

Cosentyx is contraindicated in patients with a history of hypersensitivity to secukinumab or any of its excipients. This means that individuals who have experienced an allergic reaction to Cosentyx or any of its components should avoid using it.

Pregnancy and Breastfeeding

Cosentyx is not recommended for use during pregnancy or breastfeeding. While there are no adequate studies on the use of Cosentyx in pregnant women, animal studies have shown that it can cause harm to the developing fetus. Additionally, it is not known whether secukinumab is excreted in human milk, and its effects on the breastfed infant are unknown.

Pediatric Patients

Cosentyx is not recommended for use in pediatric patients under the age of 18 years. The safety and efficacy of Cosentyx in this population have not been established.

Patients with Active Infections

Patients with active infections, including tuberculosis, should avoid using Cosentyx. Cosentyx can increase the risk of reactivation of latent tuberculosis and other infections.

Patients with a History of Crohn's Disease or Ulcerative Colitis

Patients with a history of Crohn's disease or ulcerative colitis should avoid using Cosentyx. While Cosentyx has been shown to be effective in treating psoriasis and psoriatic arthritis, it may exacerbate inflammatory bowel disease.

Patients with a History of Malignancy

Patients with a history of malignancy, including lymphoma, should avoid using Cosentyx. While there have been no reports of lymphoma in patients treated with Cosentyx, the medication has been shown to increase the risk of malignancy in animal studies.

Patients with a History of Hepatitis B or C

Patients with a history of hepatitis B or C should avoid using Cosentyx. While Cosentyx has not been shown to increase the risk of hepatitis, it may exacerbate existing liver disease.

Patients Taking Immunosuppressive Therapies

Patients taking immunosuppressive therapies, including corticosteroids, should avoid using Cosentyx. Cosentyx can increase the risk of infections and may interact with immunosuppressive therapies.

Patients with a History of Heart Problems

Patients with a history of heart problems, including heart failure, should avoid using Cosentyx. While Cosentyx has not been shown to increase the risk of heart problems, it may exacerbate existing heart disease.

Patients with a History of Kidney or Liver Disease

Patients with a history of kidney or liver disease should avoid using Cosentyx. While Cosentyx has not been shown to increase the risk of kidney or liver disease, it may exacerbate existing disease.

Patients Taking Certain Medications

Patients taking certain medications, including biologics, should avoid using Cosentyx. Cosentyx may interact with these medications and increase the risk of adverse effects.

Conclusion

Cosentyx is a powerful medication that can be effective in treating various autoimmune diseases. However, it is not suitable for everyone. Patients with a history of hypersensitivity, pregnancy, breastfeeding, pediatric patients, active infections, inflammatory bowel disease, malignancy, hepatitis, immunosuppressive therapies, heart problems, kidney or liver disease, or taking certain medications should avoid using Cosentyx. It is essential to discuss the potential risks and benefits of Cosentyx with a healthcare provider before starting treatment.

FAQs

1. Who should avoid using Cosentyx?

Patients with a history of hypersensitivity, pregnancy, breastfeeding, pediatric patients, active infections, inflammatory bowel disease, malignancy, hepatitis, immunosuppressive therapies, heart problems, kidney or liver disease, or taking certain medications should avoid using Cosentyx.

2. Is Cosentyx safe for use during pregnancy?

No, Cosentyx is not recommended for use during pregnancy. While there are no adequate studies on the use of Cosentyx in pregnant women, animal studies have shown that it can cause harm to the developing fetus.

3. Can Cosentyx be used in pediatric patients?

No, Cosentyx is not recommended for use in pediatric patients under the age of 18 years. The safety and efficacy of Cosentyx in this population have not been established.

4. Can Cosentyx increase the risk of infections?

Yes, Cosentyx can increase the risk of infections, including tuberculosis and other opportunistic infections.

5. Can Cosentyx interact with other medications?

Yes, Cosentyx may interact with other medications, including biologics, and increase the risk of adverse effects.

Cited Sources:

1. Cosentyx Prescribing Information. Novartis Pharmaceuticals Corporation.
2. DrugPatentWatch.com. Secukinumab (Cosentyx) Patent Expiration.
3. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Psoriasis.
4. American College of Rheumatology. Psoriatic Arthritis.
5. Centers for Disease Control and Prevention. Tuberculosis.
6. World Health Organization. Hepatitis B.
7. World Health Organization. Hepatitis C.
8. National Institute of Diabetes and Digestive and Kidney Diseases. Inflammatory Bowel Disease.
9. National Cancer Institute. Malignancy.
10. American Heart Association. Heart Failure.