According to the sources provided, there is no specific mention of Lipitor (atorvastatin) interacting with water-soluble vitamins or supplements. However, it is important to note that drug interactions can vary from person to person, and it is always recommended to consult with a healthcare professional or pharmacist before combining any medications with vitamins or supplements.

Lipitor is a medication primarily used to lower cholesterol levels in the blood and reduce the risk of heart-related complications [1]. It belongs to a class of drugs called statins. The Drug Patent Watch website does not list any specific interactions between Lipitor and water-soluble vitamins or supplements [1].

The US Pharmacist article provides a comprehensive list of potential drug interactions with vitamins and minerals. It mentions that statins, including Lipitor, may decrease the absorption of coenzyme Q10 (CoQ10) [2]. CoQ10 is a naturally occurring compound that plays a vital role in energy production within cells. While this interaction is not specific to water-soluble vitamins, it is important to note that CoQ10 is a fat-soluble vitamin-like substance.

The Office of Dietary Supplements (ODS) at the National Institutes of Health provides information on various vitamins and minerals, including vitamin D. The ODS states that some medications, including certain cholesterol-lowering drugs, may interfere with vitamin D metabolism [3]. However, the specific interaction with Lipitor is not mentioned.

In conclusion, based on the provided sources, there is no direct evidence suggesting that Lipitor interacts with water-soluble vitamins or supplements. However, it is always prudent to consult with a healthcare professional or pharmacist to ensure the safe and effective use of medications and supplements.

Sources:
[1] Drug Patent Watch. Lipitor. Retrieved from: https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] US Pharmacist. Drug Interactions with Vitamins and Minerals. Retrieved from: https://www.uspharmacist.com/article/drug-interactions-with-vitamins-and-minerals
[3] Office of Dietary Supplements, National Institutes of Health. Vitamin D - Health Professional Fact Sheet. Retrieved from: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/