Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the body. It belongs to a class of drugs called statins. While taking Lipitor, it is important to be cautious of any potential drug interactions, especially with over-the-counter (OTC) painkillers.

According to DrugPatentWatch [1], Lipitor has several drug interactions, including with OTC painkillers such as aspirin, ibuprofen, and naproxen. These medications may increase the risk of side effects such as stomach bleeding or kidney problems.

GoodRx [2] also lists aspirin, ibuprofen, and naproxen as potential drug interactions with Lipitor. It is recommended to avoid taking these medications together unless directed by a healthcare provider.

Drugs.com [3] specifically notes that acetaminophen (Tylenol) is safe to take with Lipitor. However, it is important to always consult with a healthcare provider before taking any new medications, including OTC painkillers, while on Lipitor.

In conclusion, while taking Lipitor, it is important to be cautious of potential drug interactions with OTC painkillers. Aspirin, ibuprofen, and naproxen should be avoided unless directed by a healthcare provider, while acetaminophen (Tylenol) is considered safe to take with Lipitor. It is always recommended to consult with a healthcare provider before taking any new medications while on Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/atorvastatin/interactions
[3] https://www.drugs.com/drug-interactions/atorvastatin-with-tylenol-276-0-11-12.html