Alcohol consumption can have a negative impact on the effectiveness of statins, which are drugs used to lower cholesterol levels in the blood [2]. Statins work by blocking the enzyme HMG-CoA reductase, which is responsible for producing cholesterol in the liver. However, when alcohol is consumed, it can interfere with the liver's ability to metabolize statins, causing an increase in their concentration in the blood and potentially leading to side effects such as muscle pain, weakness, and liver damage [2][3].

Additionally, alcohol can increase triglyceride levels in the blood, which is a type of fat that can contribute to the development of heart disease. Statins are effective in lowering triglyceride levels, but when combined with alcohol consumption, their ability to do so may be reduced [2].

It is recommended that individuals taking statins limit their alcohol consumption to no more than one drink per day for women and two drinks per day for men [2][3]. It is also important to talk to a healthcare provider about any potential interactions between alcohol and statins, as well as any other medications being taken [3].

Sources:
[2] https://www.medicalnewstoday.com/articles/statins-and-alcohol
[3] https://www.health.harvard.edu/newsletter_article/do-alcohol-and-statins-mix