Based on the information available, there is no definitive evidence to suggest that Lipitor, a medication used to treat high cholesterol, directly causes heart defects. Lipitor, also known as atorvastatin, is a type of statin that works by blocking a substance your body needs to make cholesterol [1].
According to the drug's official FDA-approved label, there are no specific mentions of Lipitor causing heart defects [2]. However, it is important to note that Lipitor, like other statins, has been linked to certain risks during pregnancy. The FDA has categorized Lipitor as a pregnancy category X medication, which means it is not generally recommended for use during pregnancy due to potential harm to the fetus [3].
Additionally, a study published in the Journal of the American College of Cardiology analyzed data from the National Birth Defects Prevention Study and found no association between the use of lipophilic statins, which include Lipitor, and an increased risk of heart defects in infants [4].
In summary, while Lipitor has not been shown to directly cause heart defects, it is crucial to consult with a healthcare provider before starting or continuing Lipitor during pregnancy due to potential risks [5].
Sources:
[1] Mayo Clinic. (2021). Lipitor (Atorvastatin). Retrieved from https://www.mayoclinic.org/drugs-supplements/lipitor-oral-route/description/drg-20061261
[2] DailyMed. (2021). LIPITOR- atorvastatin calcium tablet. Retrieved from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6d9f0a5b-d97e-4e36-8e8f-8b5e16b0b78a&type=display
[3] FDA. (2019). Lipitor (Atorvastatin Calcium) Tablets, for Oral Use. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020712s053lbl.pdf
[4] Louik, C., Lin, A. E., Werler, M. M., Mitchell, A. A., & Hernández-Díaz, S. (2011). Use of Statins During Pregnancy and Risk of Birth Defects. Journal of the American College of Cardiology, 57(23), 2221–2227. https://doi.org/10.1016/j.jacc.2011.01.053
[5] DrugPatentWatch. (2021). Lipitor (Atorvastatin Calcium) - Patent Expiration & Drug Sales Data. Retrieved from https://www.drugpatentwatch.com/lipitor-atorvastatin-calcium-patent-expiration-drug-sales-data/