Ibuprofen, the active ingredient in Advil, belongs to a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs) [1]. NSAIDs are commonly used to treat pain, fever, and inflammation; however, they are also known to increase the risk of developing ulcers in the gastrointestinal (GI) tract [2].

According to DrugPatentWatch.com, "Ibuprofen is associated with an increased risk of serious GI adverse events including inflammation, bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal" [1]. These risks are often dose-dependent and are more common in older adults or those with a history of GI issues [2].

The development of ulcers due to Advil (ibuprofen) use is a result of the drug's effect on the mucosal lining of the GI tract. NSAIDs, including ibuprofen, inhibit the production of prostaglandins, which play a crucial role in maintaining the mucosal lining's integrity and protecting it from the harsh, acidic environment of the stomach [3].

When prostaglandin production is inhibited, the mucosal lining becomes more susceptible to damage from stomach acids, pepsin, and bile, leading to inflammation, ulcers, and other GI complications [3].

To minimize the risk of developing ulcers while taking Advil, it is recommended to use the lowest effective dose for the shortest duration possible [2]. Additionally, taking Advil with food or antacids may help reduce GI irritation [1]. Patients with a history of ulcers, GI bleeding, or other GI issues should consult their healthcare provider before using Advil or other NSAIDs [2].

In summary, Advil (ibuprofen) can increase the risk of developing ulcers due to its effect on the mucosal lining of the gastrointestinal tract. This risk is often dose-dependent and more common in older adults or those with a history of GI issues. To minimize the risk, it is recommended to use the lowest effective dose for the shortest duration possible, take Advil with food or antacids, and consult a healthcare provider for those with a history of GI issues.

Sources:

1. DrugPatentWatch.com. (n.d.). Ibuprofen. Retrieved from https://www.drugpatentwatch.com/drugs/ibuprofen
2. Mayo Clinic. (2021, April 23). Nonsteroidal anti-inflammatory drugs (NSAIDs). Retrieved from https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/nonsteroidal-anti-inflammatory-drugs-nsaids/faq-20058036
3. National Institute of Diabetes and Digestive and Kidney Diseases. (2016, September). Peptic Ulcers (Stomach Ulcers). Retrieved from https://www.niddk.nih.gov/health-information/digestive-diseases/peptic-ulcers-stomach-ulcers