Advil, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain and reduce inflammation. According to the NHS [2], Advil should be taken with or after food to prevent stomach upset. The recommended dose for adults is 200-400mg every four to six hours, up to a maximum of 1,200mg per day. However, it is important to note that the dosage may vary depending on the condition being treated and the individual's medical history.

As for the best time to take Advil, MercyCare [3] suggests taking it at the first sign of pain or discomfort, rather than waiting until the pain becomes severe. This can help to reduce the amount of medication needed and may provide quicker relief. Additionally, it is recommended to take Advil at the same time each day to maintain a consistent level of the drug in the body.

It is also important to note that Advil should not be taken for extended periods of time without consulting a healthcare provider. Long-term use of NSAIDs can increase the risk of gastrointestinal bleeding, kidney damage, and other health problems.

In conclusion, the best time to take Advil is with or after food, at the first sign of pain or discomfort, and at the same time each day. However, it is important to follow the recommended dosage and not to use Advil for extended periods of time without consulting a healthcare provider.

Sources:
[2] https://www.nhs.uk/medicines/ibuprofen-for-adults/how-and-when-to-take-ibuprofen/
[3] https://www.mercycare.org/healthy-living/health-education/tylenol--advil--when-to-use-which/
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL