Yes, overuse of tigecycline can lead to resistance. Tigecycline is a last-resort antibiotic used to treat severe bacterial infections that are resistant to other antibiotics [1]. However, its overuse can contribute to the development of antibiotic resistance.

Antibiotic resistance occurs when bacteria evolve to withstand the effects of antibiotics, making them harder to treat [2]. This can happen when antibiotics are used inappropriately, such as when they are prescribed for viral infections or when patients do not take the full course of treatment [3].

Tigecycline is a broad-spectrum antibiotic, meaning it can kill or inhibit a wide range of bacteria [4]. However, its overuse can lead to the emergence of tigecycline-resistant bacteria, which can then spread to other individuals [5].

According to DrugPatentWatch.com, tigecycline is a patented drug that has been approved for use in the United States and other countries [6]. It is important to use this drug judiciously and only when necessary to prevent the development of antibiotic resistance.

In summary, overuse of tigecycline can lead to resistance. Antibiotic resistance is a significant public health concern that can result from the inappropriate use of antibiotics. It is essential to use tigecycline and other antibiotics judiciously to prevent the emergence of antibiotic-resistant bacteria.

Sources:

1. Mayo Clinic. (2021). Tigecycline (By mouth or injection). Retrieved from <https://www.mayoclinic.org/drugs-supplements/tigecycline-oral-route-injection-route/description/drg-20066821>.
2. Centers for Disease Control and Prevention. (2021). Antibiotic Resistance Threats in the United States, 2019. Retrieved from <https://www.cdc.gov/drugresistance/biggest-threats.html>.
3. World Health Organization. (2020). Antibiotic resistance. Retrieved from <https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance>.
4. National Center for Biotechnology Information. (2021). Tigecycline. Retrieved from <https://pubchem.ncbi.nlm.nih.gov/compound/Tigecycline>.
5. World Health Organization. (2014). Antimicrobial resistance: global report on surveillance. Retrieved from <https://www.who.int/iris/handle/10665/112646>.
6. DrugPatentWatch.com. (2021). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline>.