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How does lipitor dosage adjust for kidney disease?

See the DrugPatentWatch profile for lipitor

Lipitor, also known as atorvastatin, is a medication commonly prescribed to manage high cholesterol levels. When it comes to patients with kidney disease, Lipitor dosage may need to be adjusted to ensure safe and effective treatment.

According to the information provided, the recommended starting dose of Lipitor for most patients is 10-20mg once daily, which can be increased based on the patient's response to therapy [${3}]. However, for patients with kidney disease, the dosage adjustment depends on the severity of their kidney impairment.

For patients with mild to moderate kidney impairment, no dosage adjustment is typically required [${2}]. However, for those with severe kidney impairment or end-stage renal disease (ESRD) undergoing dialysis, the maximum recommended dosage is 10mg once daily [${2}]. It is important to note that Lipitor is not removed by dialysis, and therefore, the dosing regimen should be individualized based on the patient's clinical response [${2}].

Furthermore, healthcare providers should monitor kidney function in patients taking Lipitor, especially those with pre-existing kidney disease [${3}]. This is because statins, the class of medication to which Lipitor belongs, have been associated with rare cases of acute kidney injury [${3}].

In summary, the dosage of Lipitor may need to be adjusted for patients with kidney disease, depending on the severity of their kidney impairment. Mild to moderate kidney impairment typically does not require dosage adjustment, while severe kidney impairment or ESRD undergoing dialysis requires a maximum dosage of 10mg once daily. Healthcare providers should monitor kidney function in patients taking Lipitor, especially those with pre-existing kidney disease.

Sources:

* <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
* <https://reference.medscape.com/drug/lipitor-atorvaliq-atorvastatin-342446>
* <https://www.aafp.org/pubs/afp/issues/2007/0515/p1487.html>


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