Based on the provided sources, there is no direct evidence to suggest that ibuprofen interferes with the effectiveness of Lipitor (atorvastatin). However, it is always important to consult with a healthcare professional or pharmacist before combining any medications.

The first source, DrugPatentWatch, provides information about the drug ibuprofen. While it offers details about the drug's patent status, it does not mention any specific interactions with Lipitor.

The second source, GoodRx, provides information about drug interactions with atorvastatin. It does not list ibuprofen as an interaction with Lipitor. However, it is worth noting that the list of interactions on GoodRx is not exhaustive, and it is always best to consult a healthcare professional for personalized advice.

The third source, COVID-19 Treatment Guidelines by the National Institutes of Health, provides information about drug interactions involving ritonavir-boosted nirmatrelvir (Paxlovid), a medication used to treat COVID-19. This source does not mention any specific interaction between ibuprofen and Paxlovid, and it does not mention Lipitor.

In summary, based on the provided sources, there is no direct evidence to suggest that ibuprofen interferes with the effectiveness of Lipitor. However, it is essential to consult with a healthcare professional or pharmacist for personalized advice regarding the combination of these medications.

Sources:
[1] DrugPatentWatch - https://www.drugpatentwatch.com/p/tradename/IBUPROFEN
[2] GoodRx - https://www.goodrx.com/atorvastatin/interactions
[3] COVID-19 Treatment Guidelines - https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/