Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the sources provided, it is recommended to take Lipitor with or without food, at any time of the day, as long as it is taken at the same time each day . The NHS website suggests that taking Lipitor with food may help reduce the risk of stomach upset . However, it is important to note that certain foods, such as grapefruit or grapefruit juice, can interact with Lipitor and increase the risk of side effects. Therefore, it is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor . It is always best to consult with a healthcare provider or pharmacist for specific instructions on how to take Lipitor, as individual circumstances may vary .