Lipitor is a medication that is used to lower cholesterol levels in the blood. It works by inhibiting an enzyme in the liver that is responsible for producing cholesterol [1]. There is limited information available on how Lipitor affects antidepressant absorption. However, it is important to note that grapefruit and grapefruit juice can interact with Lipitor and increase the risk of side effects [2].

Grapefruit contains compounds that can interfere with the enzymes in the liver that break down certain medications, including Lipitor. This can cause more of the medication to be absorbed into the bloodstream, which can increase the risk of side effects [2]. The same compounds in grapefruit can also interact with some antidepressants, including selective serotonin reuptake inhibitors (SSRIs), and increase the risk of side effects [2].

A study published in the Journal of Psychopharmacology investigated the effect of grapefruit juice on the absorption of the antidepressant sertraline in healthy volunteers. The study found that grapefruit juice increased the absorption of sertraline, leading to higher blood levels of the medication [3]. While this study did not investigate the effect of Lipitor on antidepressant absorption, it suggests that medications that are metabolized by the liver can be affected by grapefruit juice.

In conclusion, there is limited information available on how Lipitor affects antidepressant absorption. However, grapefruit and grapefruit juice can interact with Lipitor and increase the risk of side effects. These same compounds in grapefruit can also interact with some antidepressants and increase the risk of side effects. It is important to talk to a healthcare provider about any potential drug interactions before starting a new medication [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.nhs.uk/common-health-questions/medicines/does-grapefruit-affect-my-medicine/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822840/