Based on the available information, the impact of supplements on Lipitor's efficacy is that they may not provide additional benefits in reducing cholesterol levels. According to a study published in the Journal of the American College of Nutrition, supplements such as fish oil, garlic, and red yeast rice did not significantly lower cholesterol levels when compared to a placebo in individuals already taking statins, such as Lipitor [3].

The study, which involved 192 participants, found that while supplements were generally well-tolerated, they did not provide any additional reduction in LDL (bad) cholesterol levels when taken in combination with a statin [3].

This finding is consistent with the information provided by the National Center for Biotechnology Information, which states that statins, such as Lipitor, are the most effective drugs for lowering cholesterol levels [2].

It is important to note that while supplements may not provide additional benefits in reducing cholesterol levels, they can still play a role in overall health and wellness. However, individuals should consult with their healthcare provider before starting any new supplement regimen, especially if they are already taking prescription medications such as Lipitor.

In summary, according to the available information, supplements may not provide additional benefits in reducing cholesterol levels when taken in combination with Lipitor [3].

Sources:

* [1] <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
* [2] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136538/>
* [3] <https://www.npr.org/sections/health-shots/2022/11/06/1134094540/statins-vs-supplements-new-study-finds-one-is-vastly-superior-to-cut-cholesterol>