Probenecid, a medication used to treat gout and gouty arthritis, can affect the dosage of tigecycline, an antibiotic used to treat various bacterial infections. Probenecid works by increasing the concentration of certain antibiotics, such as tigecycline, in the body by decreasing their excretion by the kidneys [1].

Tigecycline is primarily eliminated by the liver, with a minor contribution from the kidneys. Therefore, probenecid's effect on tigecycline's dosage is not significant [2]. However, it is still recommended to monitor renal function and adjust tigecycline's dosage in patients with severe renal impairment [3].

In summary, while probenecid can increase the concentration of tigecycline in the body, its clinical significance is minimal due to tigecycline's primary elimination by the liver. Nonetheless, renal function should be monitored in patients taking both medications.

Sources:

1. Mayo Clinic. (2021). Probenecid (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/probenecid-oral-route/description/drg-20063393>.
2. Tygacil (tigecycline) for injection, for intravenous use. (2018). Highlights of Prescribing Information. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021857s021lbl.pdf>.
3. UpToDate. (2021). Tigecycline: Drug Information. Retrieved from <https://www.uptodate.com/contents/tigecycline-drug-information>.
4. DrugPatentWatch. (2021). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline>.