Combining Lipitor (atorvastatin) and ibuprofen can increase the risk of developing certain side effects. Lipitor is a medication used to lower cholesterol levels, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation.

According to Drug Patent Watch [1], there are no known drug interactions between Lipitor and ibuprofen. However, Drugs.com [2] warns that taking these two medications together may increase the risk of developing muscle-related side effects such as myopathy or rhabdomyolysis. Myopathy is a condition that causes muscle weakness and pain, while rhabdomyolysis is a more severe condition that can cause muscle breakdown and kidney damage.

Additionally, Verywell Health [3] notes that NSAIDs like ibuprofen can reduce the effectiveness of statins like Lipitor, potentially leading to higher cholesterol levels. It is important to note that not everyone who takes Lipitor and ibuprofen together will experience these side effects, and the risk may be higher for those who take high doses of these medications or have preexisting medical conditions.

In conclusion, while there are no known drug interactions between Lipitor and ibuprofen, taking these two medications together may increase the risk of developing muscle-related side effects and reduce the effectiveness of Lipitor. It is important to consult with a healthcare provider before taking any new medications or changing your current medication regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.drugs.com/drug-interactions/ibuprofen-with-lipitor-1310-0-276-128.html
[3] https://www.verywellhealth.com/statin-side-effects-and-drug-interactions-698202