Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the sources provided, it is unclear whether Lipitor can cause side effects when combined with high-fat meals. However, it is recommended to take Lipitor with or without food, and to avoid consuming grapefruit or grapefruit juice while taking this medication.

The first source [1] provides information about the drug Lipitor, including its active ingredient, dosage, and expiration date. However, it does not mention anything about Lipitor's potential side effects when combined with high-fat meals.

The second source [2] is a book chapter that discusses the pharmacology and clinical use of atorvastatin. It mentions that the absorption of atorvastatin is not affected by food, but it does not provide any information about potential side effects when taken with high-fat meals.

The third source [3] is from the Mayo Clinic, a reputable medical organization. It lists the common and rare side effects of atorvastatin and ezetimibe, a combination medication that includes Lipitor. The side effects include muscle pain, weakness, and tenderness, but there is no mention of any side effects related to high-fat meals.

In conclusion, while Lipitor is recommended to be taken with or without food, it is unclear whether it can cause side effects when combined with high-fat meals. It is important to follow the medication instructions and avoid consuming grapefruit or grapefruit juice while taking Lipitor. If you experience any unusual symptoms while taking Lipitor, you should contact your healthcare provider immediately.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/books/NBK542212/
[3] https://www.mayoclinic.org/drugs-supplements/atorvastatin-and-ezetimibe-oral-route/side-effects/drg-20060992?p=1