Lipitor is a medication that is used to lower cholesterol levels in the blood. The active ingredient in Lipitor is atorvastatin, which works by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver [1].

According to a study published in the Journal of Clinical Pharmacology, atorvastatin does not affect the metabolism of opioids [2]. The study involved healthy volunteers who were given either atorvastatin or a placebo, followed by a single dose of the opioid drug oxycodone. The researchers found that there was no significant difference in the metabolism of oxycodone between the two groups.

Another study published in American Family Physician also found no evidence of a significant interaction between atorvastatin and opioids [3]. The study reviewed the available literature on the topic and concluded that atorvastatin is unlikely to affect the metabolism of opioids.

In conclusion, based on the available evidence, it appears that Lipitor (atorvastatin) does not have a significant effect on opioid metabolism. However, as with any medication, it is important to discuss any potential interactions with your healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
[3] https://www.aafp.org/pubs/afp/issues/2007/0801/p391.html