Lipitor is a medication used to lower cholesterol levels in the blood. It is a type of statin drug that inhibits the enzyme HMG-CoA reductase, which plays a key role in cholesterol synthesis [1]. Lipitor toxicity can occur when the drug is taken in excess or when the body is unable to metabolize it properly.

According to a study published in the journal Circulation Research, the onset of Lipitor toxicity can vary depending on the dose and duration of use. The study found that high doses of Lipitor can lead to acute liver injury, which can occur within weeks or months of starting the medication [2]. However, the study also noted that most cases of Lipitor toxicity are mild and do not result in serious health consequences.

Another study published in the journal Case Reports in Cardiology reported a case of Lipitor toxicity in a patient who had been taking the drug for over a year. The patient experienced muscle pain and weakness, which are common side effects of Lipitor. The symptoms worsened over time and eventually led to rhabdomyolysis, a serious condition in which muscle tissue breaks down and releases harmful substances into the bloodstream [3].

In conclusion, Lipitor toxicity can occur within weeks or months of starting the medication, especially at high doses. However, most cases of Lipitor toxicity are mild and do not result in serious health consequences. Patients who experience muscle pain or weakness while taking Lipitor should consult their healthcare provider immediately to prevent the development of more serious complications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.118.312782
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019601/