Vascepa and fish oil are both used to lower triglyceride levels in patients with high levels of triglycerides. However, Vascepa contains a high concentration of EPA, while fish oil contains a mixture of EPA and DHA.

According to a study published in the Journal of Clinical Lipidology [3], Vascepa has been shown to be more effective than fish oil in reducing triglyceride levels. The study found that Vascepa reduced triglyceride levels by 33% compared to a 27% reduction with fish oil. Furthermore, Vascepa was found to be more effective in reducing non-HDL cholesterol levels, which is a risk factor for cardiovascular disease.

Another study published in the American Journal of Cardiovascular Drugs [2] found that Vascepa was more effective than Lovaza, another prescription omega-3 medication, in reducing triglyceride levels. The study found that Vascepa reduced triglyceride levels by 21.5% compared to a 10.1% reduction with Lovaza.

It is important to note that Vascepa is a prescription medication, while fish oil is available over-the-counter. Vascepa is also more expensive than fish oil.

In conclusion, based on the provided sources, Vascepa has been shown to be more effective than fish oil in reducing triglyceride levels and non-HDL cholesterol levels. However, it is important to consult with a healthcare provider to determine the best treatment plan for individual patients.

Sources:
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588662/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671468/
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.drugs.com/medical-answers/vascepa-fish-oil-3553311/