When considering the concomitant use of Advil (ibuprofen) and antidepressants, it is essential to be aware of the potential side effects. Ibuprofen, the active ingredient in Advil, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain, fever, and inflammation. Antidepressants are medications prescribed to manage various mental health disorders, such as depression and anxiety.

Potential side effects of mixing Advil and antidepressants may include:

1. Gastrointestinal issues: NSAIDs like ibuprofen can increase the risk of gastrointestinal side effects, such as stomach ulcers and bleeding, especially when taken concomitantly with corticosteroids or anticoagulants [${1}]. Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), have also been associated with gastrointestinal symptoms [${2}].

2. Increased risk of bleeding: NSAIDs can inhibit platelet aggregation, increasing the risk of bleeding, especially when taken with anticoagulants or other medications that affect hemostasis [${1}]. Antidepressants, particularly SSRIs, have also been associated with an increased risk of bleeding [${2}].

3. Kidney damage: NSAIDs, including ibuprofen, can impair renal function, particularly in older adults or those with preexisting kidney issues [${1}]. Antidepressants, particularly SSRIs and SNRIs, have also been associated with kidney damage in rare cases [${2}].

4. Hyponatremia: Certain antidepressants, particularly SSRIs, have been associated with a risk of developing hyponatremia (low sodium levels) due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) [${2}]. NSAIDs like ibuprofen do not directly cause hyponatremia but can exacerbate this condition if it is already present [${1}].

5. Drug interactions: Specific antidepressants may interact with ibuprofen, leading to altered drug levels and potential adverse effects. For instance, fluoxetine, a commonly prescribed SSRI, can increase the plasma concentration of ibuprofen, potentially leading to increased side effects [${2}].

It is crucial to consult a healthcare professional or pharmacist before combining any medications, including Advil and antidepressants, to ensure safety and minimize the risk of potential side effects.

Sources:

1. <https://www.drugpatentwatch.com/p/tradename/ADVIL>
2. <https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20044970>
3. <https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines>