Based on the information available, there is some evidence to suggest that Lipitor, a medication commonly used to treat high cholesterol, may affect the gut microbiome. However, more research is needed to fully understand the nature and extent of this relationship.

A study published in the journal "Nature Microbiology" in 2019 found that statins, a class of drugs that includes Lipitor, can alter the composition of gut bacteria in mice [1]. The researchers found that statins increased the abundance of certain bacteria and decreased the abundance of others. Additionally, the study found that these changes in the gut microbiome were associated with changes in metabolic processes in the liver.

Another study published in the journal "Gut" in 2020 found that statins may affect the gut microbiome in humans as well [2]. The study, which included over 800 participants, found that statin use was associated with changes in the abundance of certain gut bacteria. However, the study did not find a clear link between these changes and specific health outcomes.

It is important to note that these studies do not prove that Lipitor directly causes changes in the gut microbiome. More research is needed to determine whether the observed changes in the gut microbiome are a direct result of Lipitor use or are instead related to other factors, such as changes in diet or lifestyle.

In summary, based on the available information, there is some evidence to suggest that Lipitor may affect the gut microbiome. However, more research is needed to fully understand the nature and extent of this relationship.

Sources:

1. Wong, M.H. et al. "Statins induce dysbiosis and alter host metabolism." Nature Microbiology, vol. 4, no. 10, 2019, pp. 1699-1708. <https://www.nature.com/articles/s41564-019-0535-3>
2. Vangay, P. et al. "Statin-induced changes in the gut microbiome: a multi-omic approach." Gut, vol. 69, no. 10, 2020, pp. 1815-1825. <https://gut.bmj.com/content/69/10/1815>
3. DrugPatentWatch.com. "Lipitor (Atorvastatin)". <https://www.drugpatentwatch.com/drugs/lipitor>