Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body. According to the sources provided, it is recommended to take Lipitor with or without food, as it does not affect the medication's effectiveness . However, it is important to note that taking Lipitor with certain foods, particularly those high in fat, may increase the risk of side effects such as muscle pain and liver damage . It is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor, as it can increase the levels of the medication in the body and lead to adverse effects . Additionally, it is advised to limit the intake of saturated and trans fats while taking Lipitor, as these types of fats can increase cholesterol levels in the body and counteract the medication's effects . Overall, while Lipitor can be taken with or without food, it is important to be mindful of the types of foods consumed while taking the medication to minimize the risk of side effects and maximize its effectiveness.