Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood, while antidepressants are used to treat depression and other mental health conditions. Both medications have different mechanisms of action and are used to treat different conditions. However, taking them together can increase the risk of drug interactions and adverse effects.

According to Drug Patent Watch [1], there are no known drug interactions between Lipitor and antidepressants. However, it is important to note that this does not mean that there are no risks associated with taking these medications together. Antidepressants can affect the metabolism of Lipitor, which can increase the risk of side effects such as muscle pain, weakness, and rhabdomyolysis (a serious condition that can cause muscle breakdown and kidney damage).

A study published in the Journal of Clinical Psychopharmacology [3] found that taking Lipitor and antidepressants together can increase the risk of developing hyponatremia (low sodium levels in the blood). Hyponatremia can cause symptoms such as nausea, headache, confusion, seizures, and even coma in severe cases.

Another study published in the Journal of Clinical Psychiatry [2] found that taking Lipitor and certain antidepressants (such as fluoxetine and paroxetine) together can increase the risk of bleeding. This is because both medications can affect the function of platelets, which are responsible for blood clotting.

In conclusion, while there are no known drug interactions between Lipitor and antidepressants, taking them together can increase the risk of adverse effects such as muscle pain, weakness, rhabdomyolysis, hyponatremia, and bleeding. Therefore, it is important to discuss the risks and benefits of taking these medications together with your healthcare provider before starting or stopping any medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/28303466/
[3] https://pubmed.ncbi.nlm.nih.gov/15118494/