Lipitor is a medication used to treat high cholesterol levels. It belongs to a group of drugs called statins, which work by reducing the production of cholesterol in the liver. According to Drug Patent Watch [1], there are no known interactions between low-fat substitutes and Lipitor. However, it is important to note that some dietary supplements and grapefruit juice can interact with Lipitor and increase the risk of side effects.

There are several alternatives to statins, as listed by Healthline [2] and WebMD [3]. These include dietary changes, such as reducing saturated and trans fats, increasing fiber intake, and consuming more plant-based foods. Regular exercise, weight loss, and quitting smoking can also help to lower cholesterol levels. Additionally, there are several supplements that may help to lower cholesterol, including fish oil, plant sterols, and psyllium. However, it is important to consult with a healthcare provider before taking any supplements, as they can interact with medications and cause adverse effects.

In conclusion, there are no known interactions between low-fat substitutes and Lipitor. However, some dietary supplements and grapefruit juice can interact with Lipitor and increase the risk of side effects. It is important to consult with a healthcare provider before making any changes to your diet or taking any supplements to lower cholesterol levels.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.healthline.com/health/high-cholesterol/alternatives-statins
[3] https://www.webmd.com/cholesterol-management/features/are-there-statin-alternatives