Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels and reduce the risk of heart disease and stroke. It works by blocking an enzyme that produces cholesterol in the liver [1]. Grapefruit juice, on the other hand, contains a compound called furanocoumarin that can interfere with the body's ability to break down certain medications, including Lipitor [2].

According to a Harvard Health article, drinking grapefruit juice while taking Lipitor can increase the drug's concentration in the blood, leading to a higher risk of side effects such as muscle pain and liver damage. The article recommends avoiding grapefruit juice altogether while taking Lipitor [2].

Similarly, a Verywell Health article advises against consuming grapefruit juice while taking Lipitor or a similar medication called Zocor (simvastatin). The article explains that the interaction between grapefruit juice and these drugs can last for up to 72 hours, even after the juice has been consumed [3].

In summary, grapefruit juice can interfere with the body's ability to break down Lipitor, leading to an increased risk of side effects. It is best to avoid consuming grapefruit juice while taking Lipitor or similar medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.health.harvard.edu/heart-health/grapefruit-juice-and-statins
[3] https://www.verywellhealth.com/can-i-take-lipitor-or-zocor-with-grapefruit-juice-1124045